The Sheaff lab investigates the biochemical basis of human diseases like cancer and neurodegeneration. Projects in cancer biochemistry center on how disrupted signaling contributes to aberrant cell cycle progression and altered metabolic pathways. Collaborative drug discovery and characterization projects focus on screening chemical libraries and evaluating novel chemotherapeutic agents. Work on neurodegenerative diseases investigates the role of deregulated protein degradation by the ubiquitin-proteasome system. A third area of research involves identifying biological markers of the human stress and pain responses, which is carried out in collaboration with members of the Psychology Department.
Education and Degrees Earned
- Postdoctoral Fellowship Fred Hutchinson Cancer Research Center, Seattle,1999
- Ph.D. Chemistry University of Colorado, Boulder,1994
- B.A. Biology and Philosophy University of North Carolina at Chapel Hill 1989
Areas of Research Focus
- Cell cycle control
- Protein degradation
- Signal transduction
- Drug discovery
Previous Teaching Experience
- Graduate-level classes at the University of Minnesota.
Previous Relevant Work Experience
- 4/94 - 1/99
Post-Doctoral Research Associate, Laboratory of Dr. James Roberts, Dept. of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA.
- 4/99 – 6/06
Assistant Professor, University of Minnesota Cancer Center and Dept. of Biochemistry, Molecular Biology and Biophysics, Minneapolis, MN.
- 4/00 – 6-06
Member, University of Minnesota Stem Cell Institute.
- American Chemical Society
- National Science Foundation Panel Member