Chemical Biology

Research from the lab of Prof. Justin M. Chalker

Selective chemical probes for detection of disease biomarkers
The detection and quantification of certain biomarkers is critical to early diagnosis and treatment of human disease. In this project, we have designed a novel chemical probe that can reveal the presence of an important biomarker called cysteine sulfenic acid. This residue is found in certain proteins and is a hallmark of oxidative stress and cancer. The low abundance and transient nature of the cysteine sulfenic acid has prompted us to design a new reagent that reacts with this biomarker rapidly and generates an easily monitored fluorescent signal. We are currently using this probe in the study of oxidative stress in cells and how this information can be used for diagnostic purposes.

For more, visit the website for the Chalker Research Group